diff --git a/tests/models/qwen4_exp/test_config.py b/tests/models/qwen4_exp/test_config.py
index 45af884a86..9d30365b81 100644
--- a/tests/models/qwen4_exp/test_config.py
+++ b/tests/models/qwen4_exp/test_config.py
@@ -1,6 +1,7 @@
 # SPDX-License-Identifier: Apache-2.0
 # SPDX-FileCopyrightText: Copyright contributors to the vLLM project
 
+from importlib import import_module
 from types import SimpleNamespace
 from unittest.mock import patch
 
@@ -19,6 +20,8 @@ from vllm.models.qwen4_exp.config import (
 from vllm.models.qwen4_exp.nvidia.model_state import Qwen4ExpModelState
 from vllm.v1.worker.gpu.model_states.mamba_hybrid import MambaHybridModelState
 
+from ...utils import spawn_new_process_for_each_test
+
 
 def _text_config(**kwargs) -> Qwen4ExpTextConfig:
     values = {
@@ -89,6 +92,28 @@ def test_qwen4_exp_mtp_returns_sample_and_multi_streams() -> None:
     assert returned_multi_hidden is multi_hidden
 
 
+@spawn_new_process_for_each_test
+@pytest.mark.parametrize("backend", ["amd", "nvidia"])
+def test_qwen4_exp_mtp_remaps_mixed_precision_layer_indices(backend: str) -> None:
+    mtp_module = import_module(f"vllm.models.qwen4_exp.{backend}.mtp")
+
+    quantized_layers = {
+        "model.language_model.layers.0.mlp.experts": {"quant_algo": "NVFP4"},
+        "mtp.layers.0.mlp.experts": {
+            "quant_algo": "FP8_BLOCK_SCALES",
+            "group_size": 128,
+        },
+    }
+
+    assert mtp_module._remap_quantized_layers(quantized_layers, 48) == {
+        "model.language_model.layers.0.mlp.experts": {"quant_algo": "NVFP4"},
+        "mtp.layers.48.mlp.experts": {
+            "quant_algo": "FP8_BLOCK_SCALES",
+            "group_size": 128,
+        },
+    }
+
+
 @pytest.mark.parametrize("wrapped_config", [False, True])
 def test_qwen4_exp_mtp_override_sets_draft_config(
     wrapped_config: bool,
diff --git a/tests/quantization/test_modelopt.py b/tests/quantization/test_modelopt.py
index 151fbbf840..59a333bfe4 100644
--- a/tests/quantization/test_modelopt.py
+++ b/tests/quantization/test_modelopt.py
@@ -25,6 +25,7 @@ from vllm.model_executor.kernels.linear import (
     MarlinNvFp4LinearKernel,
 )
 from vllm.model_executor.layers.attention import Attention
+from vllm.model_executor.layers.fused_moe import RoutedExperts
 from vllm.model_executor.layers.linear import UnquantizedLinearMethod
 from vllm.model_executor.layers.quantization.modelopt import (
     LINEAR_ALGOS,
@@ -224,6 +225,37 @@ def test_modelopt_mixed_precision_dispatches_every_linear_algo(algo):
     assert isinstance(method, ModelOptLinearMethod), (algo, type(method).__name__)
 
 
+@pytest.mark.parametrize("algo", ["FP8_PB_WO", "FP8_BLOCK_SCALES"])
+def test_modelopt_mixed_precision_dispatches_block_fp8_moe(algo):
+    config = ModelOptMixedPrecisionConfig.from_config(
+        {
+            "quantization": {
+                "quant_algo": "MIXED_PRECISION",
+                "quantized_layers": {
+                    "mtp.layers.48.mlp.experts": {
+                        "quant_algo": algo,
+                        "group_size": 128,
+                    }
+                },
+            }
+        }
+    )
+    layer = MagicMock(spec=RoutedExperts)
+    expected = object()
+
+    with patch(
+        "vllm.model_executor.layers.quantization.modelopt.Fp8MoEMethod",
+        return_value=expected,
+    ) as method_cls:
+        method = config.get_quant_method(layer, "mtp.layers.48.mlp.experts")
+
+    assert method is expected
+    fp8_config, called_layer = method_cls.call_args.args
+    assert called_layer is layer
+    assert fp8_config.weight_block_size == [128, 128]
+    assert fp8_config.activation_scheme == "dynamic"
+
+
 def test_modelopt_nvfp4_leaves_excluded_parallel_lm_head_unquantized():
     config = ModelOptNvFp4Config(
         is_checkpoint_nvfp4_serialized=True,
diff --git a/vllm/model_executor/layers/quantization/modelopt.py b/vllm/model_executor/layers/quantization/modelopt.py
index e2ab74c369..2abe60d7ad 100644
--- a/vllm/model_executor/layers/quantization/modelopt.py
+++ b/vllm/model_executor/layers/quantization/modelopt.py
@@ -60,6 +60,7 @@ from vllm.model_executor.layers.quantization.base_config import (
     QuantizationConfig,
     QuantizeMethodBase,
 )
+from vllm.model_executor.layers.quantization.fp8 import Fp8Config, Fp8MoEMethod
 from vllm.model_executor.layers.quantization.kv_cache import BaseKVCacheMethod
 from vllm.model_executor.layers.quantization.utils.fp8_utils import (
     FP8_SCALE_SENTINEL,
@@ -107,6 +108,11 @@ if TYPE_CHECKING:
 
 logger = init_logger(__name__)
 
+# ``FP8_PB_WO`` is ModelOpt's canonical 2D block-FP8 name. Early composed
+# Qwen3.8-Flash-Next checkpoints used ``FP8_BLOCK_SCALES`` for the same tensor
+# layout, so retain it as a checkpoint-compatibility alias.
+_BLOCK_FP8_MOE_ALGOS = ("FP8_PB_WO", "FP8_BLOCK_SCALES")
+
 # Single source of truth for the ModelOpt linear algos.
 #
 # Each entry is (owning config's name, mixed-precision sub-config attribute).
@@ -1491,11 +1497,28 @@ class ModelOptMixedPrecisionConfig(ModelOptQuantConfigBase):
         self.w4a16_nvfp4_config = w4a16_nvfp4_config
         self.mxfp8_config = mxfp8_config
 
+        block_sizes = {
+            int(layer_info.get("group_size", 128))
+            for layer_info in quantized_layers.values()
+            if layer_info.get("quant_algo", "").upper() in _BLOCK_FP8_MOE_ALGOS
+        }
+        if len(block_sizes) > 1:
+            raise ValueError(
+                "MIXED_PRECISION currently requires all block-FP8 MoE layers "
+                f"to use one group_size, got {sorted(block_sizes)}."
+            )
+        block_size = next(iter(block_sizes), 128)
+        self.fp8_block_config = Fp8Config(
+            is_checkpoint_fp8_serialized=True,
+            activation_scheme="dynamic",
+            weight_block_size=[block_size, block_size],
+        )
+
     def has_blocked_weights(self) -> bool:
         # Same gate as ModelOptFp8Config.has_blocked_weights, resolved per
         # layer: "+quant_fp8" must be on as soon as any layer is block-scaled.
         return any(
-            info.get("quant_algo", "").upper() == "FP8_PB_WO"
+            info.get("quant_algo", "").upper() in _BLOCK_FP8_MOE_ALGOS
             for info in self.quantized_layers.values()
         )
 
@@ -1730,6 +1753,8 @@ class ModelOptMixedPrecisionConfig(ModelOptQuantConfigBase):
             return build_linear_method(getattr(self, subcfg_attr), quant_algo, prefix)
 
         if isinstance(layer, RoutedExperts):
+            if quant_algo in _BLOCK_FP8_MOE_ALGOS:
+                return Fp8MoEMethod(self.fp8_block_config, layer)
             if quant_algo == "FP8":
                 return ModelOptFp8MoEMethod(
                     quant_config=self.fp8_config,
diff --git a/vllm/models/qwen4_exp/amd/mtp.py b/vllm/models/qwen4_exp/amd/mtp.py
index 5a77448eca..40ee6a6d47 100644
--- a/vllm/models/qwen4_exp/amd/mtp.py
+++ b/vllm/models/qwen4_exp/amd/mtp.py
@@ -78,6 +78,17 @@ def _remap_ignored_layers(
     return remapped
 
 
+def _remap_quantized_layers(
+    quantized_layers: dict[str, dict],
+    mtp_start_layer_idx: int,
+) -> dict[str, dict]:
+    """Map checkpoint MTP layer indices to standalone draft indices."""
+    return {
+        _remap_ignored_layers([name], mtp_start_layer_idx)[0]: layer_info
+        for name, layer_info in quantized_layers.items()
+    }
+
+
 def _remap_mtp_weight_name(name: str) -> str | None:
     """Map Qwen4Exp checkpoint paths into the standalone draft model."""
 
@@ -136,6 +147,13 @@ def _make_draft_vllm_config(
                 "exclude_modules",
                 _remap_ignored_layers(exclude_modules, mtp_start_layer_idx),
             )
+        quantized_layers = getattr(draft_quant_config, "quantized_layers", None)
+        if quantized_layers:
+            setattr(  # noqa: B010
+                draft_quant_config,
+                "quantized_layers",
+                _remap_quantized_layers(quantized_layers, mtp_start_layer_idx),
+            )
 
     draft_vllm_config = replace(
         vllm_config,
diff --git a/vllm/models/qwen4_exp/nvidia/mtp.py b/vllm/models/qwen4_exp/nvidia/mtp.py
index 1650f84a30..d12b851d68 100644
--- a/vllm/models/qwen4_exp/nvidia/mtp.py
+++ b/vllm/models/qwen4_exp/nvidia/mtp.py
@@ -77,6 +77,17 @@ def _remap_ignored_layers(
     return remapped
 
 
+def _remap_quantized_layers(
+    quantized_layers: dict[str, dict],
+    mtp_start_layer_idx: int,
+) -> dict[str, dict]:
+    """Map checkpoint MTP layer indices to standalone draft indices."""
+    return {
+        _remap_ignored_layers([name], mtp_start_layer_idx)[0]: layer_info
+        for name, layer_info in quantized_layers.items()
+    }
+
+
 def _remap_mtp_weight_name(name: str) -> str | None:
     """Map Qwen4Exp checkpoint paths into the standalone draft model."""
 
@@ -135,6 +146,13 @@ def _make_draft_vllm_config(
                 "exclude_modules",
                 _remap_ignored_layers(exclude_modules, mtp_start_layer_idx),
             )
+        quantized_layers = getattr(draft_quant_config, "quantized_layers", None)
+        if quantized_layers:
+            setattr(  # noqa: B010
+                draft_quant_config,
+                "quantized_layers",
+                _remap_quantized_layers(quantized_layers, mtp_start_layer_idx),
+            )
 
     draft_vllm_config = replace(
         vllm_config,