diff --git a/tests/quantization/test_humming_ignore.py b/tests/quantization/test_humming_ignore.py
new file mode 100644
index 0000000000..53554b1af3
--- /dev/null
+++ b/tests/quantization/test_humming_ignore.py
@@ -0,0 +1,56 @@
+# SPDX-License-Identifier: Apache-2.0
+# SPDX-FileCopyrightText: Copyright contributors to the vLLM project
+"""Tests for humming's is_layer_skipped handling of compressed-tensors
+regex ("re:") ignore entries.
+
+Regression test: compressed-tensors checkpoints (e.g. Kimi-K2.6) list ignored
+layers as regex patterns prefixed with "re:" (e.g. "re:vision_tower.*").
+humming previously substring-matched these literals, so ignored layers were
+never skipped and got (incorrectly) quantized -- which then diverged between
+the real weight-load path (falls back to unquantized) and the dummy-load path
+(stays quantized), breaking any consumer that byte-compares the two.
+"""
+
+import pytest
+
+from vllm.model_executor.layers.quantization.humming import HummingConfig
+
+# The real ignore list from Kimi-K2.6's compressed-tensors quantization_config.
+K26_IGNORE = [
+    "re:.*self_attn.*",
+    "re:.*shared_experts.*",
+    r"re:.*mlp\.(gate|up|gate_up|down)_proj.*",
+    "re:.*lm_head.*",
+    "re:vision_tower.*",
+    "re:mm_projector.*",
+]
+
+
+@pytest.mark.parametrize(
+    "prefix,expected",
+    [
+        # ignored layers (must be skipped -> stay unquantized)
+        ("vision_tower.encoder.blocks.0.mlp.fc0", True),
+        ("vision_tower.encoder.blocks.16.wo", True),
+        ("mm_projector.linear_1", True),
+        ("language_model.model.layers.0.self_attn.o_proj", True),
+        ("language_model.model.layers.0.mlp.gate_up_proj", True),
+        ("language_model.model.layers.0.mlp.down_proj", True),
+        ("language_model.model.layers.3.mlp.shared_experts.gate_proj", True),
+        ("model.lm_head", True),
+        # routed experts are NOT ignored -> must be quantized
+        ("language_model.model.layers.3.mlp.experts.383.up_proj", False),
+        ("language_model.model.layers.3.mlp.experts.0.down_proj", False),
+    ],
+)
+def test_is_layer_skipped_regex_ignore(prefix, expected):
+    cfg = HummingConfig(full_config={"ignore": K26_IGNORE})
+    assert cfg.is_layer_skipped({"ignore": K26_IGNORE}, prefix) is expected
+
+
+def test_plain_substring_entries_still_work():
+    # bitsandbytes-style modules_to_not_convert use plain substrings.
+    cfg = HummingConfig()
+    cfg_dict = {"modules_to_not_convert": ["lm_head", "vision"]}
+    assert cfg.is_layer_skipped(cfg_dict, "model.vision.encoder.fc") is True
+    assert cfg.is_layer_skipped(cfg_dict, "model.layers.0.mlp.up_proj") is False
diff --git a/vllm/model_executor/layers/quantization/humming.py b/vllm/model_executor/layers/quantization/humming.py
index 9bbbf41115..f73852e0cf 100644
--- a/vllm/model_executor/layers/quantization/humming.py
+++ b/vllm/model_executor/layers/quantization/humming.py
@@ -217,8 +217,17 @@ class HummingConfig(QuantizationConfig):
         if hasattr(self, "hf_to_vllm_mapper"):
             ignored_layers = self.hf_to_vllm_mapper.apply_list(ignored_layers)
 
-        if any(module_name in prefix for module_name in ignored_layers):
-            return True
+        for module_name in ignored_layers:
+            # compressed-tensors style entries may be regex patterns prefixed
+            # with "re:" (e.g. "re:vision_tower.*"). These must be regex-matched;
+            # plain substring matching never matches the literal "re:..." string,
+            # so ignored layers get silently quantized. Non-"re:" entries keep the
+            # existing substring behavior (e.g. bitsandbytes modules_to_not_convert).
+            if module_name.startswith("re:"):
+                if re.match(module_name[3:], prefix):
+                    return True
+            elif module_name in prefix:
+                return True
         if "lm_head" in prefix:
             return True